• Based upon these findings the

  2025-02-26

  

  Based upon these findings, the 12S-lipoxygenase seems to increase membrane excitability by specifically inhibiting M-type K+ channels. The 12S-lipoxygenase is expressed in many parts of mammalian atp citrate lyase inhibitor including the cerebrum, cerebellum, hypothalamus, basal ganglia, hippocampu

• As one of emerging high throughout methods metabolomics dete

  2025-02-26

  

  As one of emerging high-throughout methods, metabolomics detects metabolites which are ultimate response of biological systems to environmental changes [14]. Metabolomics uncovers metabolic alteration at the systems level. Comparison of global metabolic profiling reflects some unidentified biologica

• AKT activity is also self limiting through

  2025-02-26

  

  AKT activity is also self-limiting through its substrate GSK3β; the kinase activity of which is negatively regulated by AKT phosphorylation (Fig. 3; Li, Liu, & Gao, 2009). GSK3β activation results in phosphorylation and subsequent ubiquitin mediated degradation of PHLPP (Li et al., 2009). AKT activa

• Activation of AhR is also known to

  2025-02-26

  

  Activation of AhR is also known to upregulate the expression of AhRR (AhR repressor), an inhibitor protein of AhR [29]. However, the exact mechanism by which AhRR represses AhR signaling is not well understood. The initial study by Mimura and colleagues suggested that AhRR is capable of directly com

• To further clarify the vascular cell types expressing AR

  2025-02-26

  

  To further clarify the vascular cell types expressing AR subtypes, double immunofluorescence staining for ARs and vascular endothelial FMK or vascular smooth muscles was performed. As shown in Fig. 3, Fig. 4, overlay images show the expression of all ARs subtypes that we examined in vascular endoth

• Pituitary adenylate cyclase activating polypeptide PACAP is

  2025-02-26

  

  Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the secretin/growth hormone-releasing hormone (GHRH)/vasoactive intestinal peptide (VIP) family, with potent anti-inflammatory and potent cytoprotective properties [[6], [7], [8], [9], [10], [11], [12], [13]]. PACAP exists as

• While A Rs communicate mainly with

  2025-02-26

  

  While A1Rs communicate mainly with the D1R subtype [36], A2AR and D2R interaction occurs mainly in basal ganglia. D2Rs colocalizes with A2ARs in this LB42708 area where they are preferentially localized postsynaptically in the soma and dendrites of GABAergic striatopallidal neurons [69]. This intera

• br Introduction Epilepsy is characterized by spontaneous rec

  2025-02-26

  

  Introduction Epilepsy is characterized by spontaneous recurrent seizures and represents one of the most frequent neurological diseases affecting about 60 million people worldwide (McNamara, 1999). It is estimated that up to 50% of all cases are triggered by “initial precipitating injuries”, such

• br Introduction Myasthenia gravis MG is an autoimmune diseas

  2025-02-26

  

  Introduction Myasthenia gravis (MG) is an autoimmune disease in which antibodies against targets on the postsynaptic muscle membrane cause neuromuscular transmission failure. About 85% of patients with MG have autoantibodies against Cisplatin receptor (AChR) [1]. In AChR negative MG patients ant

• A rational approach for the

  2025-02-26

  

  A rational approach for the design of new steroid compounds as possible competitive inhibitors of CYP17 include chemical modification at C17 of the enzyme's natural substrates, pregnenolone (1) and progesterone (2), introducing groups with moderate to strong dipole properties at C20, such as oxime a

• MafB a member of the Maf protein family

  2025-02-26

  

  MafB, a member of the Maf protein family, is essential for terminal differentiation of macrophages (Kelly et al., 2000). The phagocytic activity of polystyrene beads was found to be enhanced in VU 0155069 with exogenous expression of MafB (Tillmanns et al., 2007). However, in alveolar macrophages o

• br Autophagy and cell death pathways

  2025-02-26

  

  Autophagy and cell death pathways in ischemic stroke Although very important for the effects on post-ischemic nhs biotin injury, autophagy is not the only mechanism of action involved in cell death. Necrosis and apoptosis are two other distinct forms of cell death with great difference in morpho

• Recent findings imply that proper Na K ATPase function

  2025-02-26

  

  Recent findings imply, that proper Na+/K+-ATPase function is crucial for unimpaired development of the vertebrate heart. Targeted knockout of Na+/K+-ATPase α1 in mice led to early embryonic lethality whereas heterozygous knockout mice displayed severe hypocontractile hearts [52]. Pharmacological inh

• br Introduction Lung cancer is

  2025-02-26

  

  Introduction Lung cancer is the leading cause of cancer death worldwide and is one of the most refractory of solid tumors along with pancreatic cancer. Since 1975 there have been notable improvements in the 5-year survival rate of patients with lung cancer [1]. This improvement in survival is tho

• As shown in B the recombinant human LOX nM

  2025-02-26

  

  As shown in B, the recombinant human 15-LOX-1 (30nM) showed a time-dependent increase in fluorescent signal, and signal development was almost completed within 20min in the presence of 50μM arachidonic ambrisentan drug and 5μM DHR. For both purified enzyme and cell lysates, the enzyme activities dis

15966 records 5/1065 page Previous Next 12345 下5页 Last page