ARCA EGFP mRNA: Transforming mRNA Reporter Controls for P...

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Explore how ARCA EGFP mRNA, a direct-detection reporter mRNA, redefines mRNA transfection control and fluorescence-based assay precision in mammalian cell research. This in-depth analysis uncovers advanced mechanistic insights, practical optimization, and emerging applications for next-generation gene expression studies.

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Explore how 2'3'-cGAMP (sodium salt) enables precise, cell-type–specific modulation of the cGAS-STING pathway. This in-depth analysis reveals new strategies for advancing immunotherapy and antiviral research beyond conventional approaches.

EZ Cap™ Human PTEN mRNA (ψUTP): Redefining mRNA Delivery ...

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Discover how EZ Cap™ Human PTEN mRNA (ψUTP) empowers breakthrough studies in mRNA stability enhancement, immune evasion, and PI3K/Akt pathway inhibition. This article uniquely explores integrated delivery strategies and mechanistic insights beyond conventional applications.

Rotenone: Advanced Insights into Mitochondrial Complex I ...

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Explore the multifaceted role of Rotenone as a mitochondrial Complex I inhibitor and mitochondrial dysfunction inducer in neurodegenerative disease research. This article uniquely integrates mechanistic detail, metabolic regulation, and emerging proteostasis insights for advanced research applications.

Sulfo-Cy7 NHS Ester: Transforming In Vivo Imaging of Host...

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Discover how Sulfo-Cy7 NHS Ester, a sulfonated near-infrared fluorescent dye, enables unprecedented precision and biological sensitivity in live imaging of host–microbe interactions and placental disorders. This article uniquely explores mechanistic applications in translational research and advanced bioimaging.

Clozapine N-oxide (CNO): Revolutionizing Chemogenetic Cir...

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Explore how Clozapine N-oxide (CNO), a selective DREADDs activator and metabolite of clozapine, empowers advanced chemogenetic studies, from neuronal activity modulation to caspase signaling research. This article uncovers novel applications and technical insights not found in existing literature.

EZ Cap™ Human PTEN mRNA (ψUTP): Enhancing Functional mRNA...

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Explore the scientific utility of EZ Cap™ Human PTEN mRNA (ψUTP) in mRNA-based gene expression studies, highlighting its advantages for cancer research and PI3K/Akt signaling pathway inhibition. This article discusses novel strategies for stable, immunoevasive mRNA delivery using advanced Cap1 and pseudouridine modifications.

br Materials and methods br Results br Discussion

2025-03-03

Materials and methods Results Discussion In the present study, we identified HBP1 as a novel substrate of AKT. This was demonstrated by in vitro phosphorylation assays and western blotting using phosphosite-specific antibodies. Three sites were identified by mass spectrometry and mutagenesi

In summary the role of HT and differe http

2025-03-03

In summary, the role of 5-HT and different types of 5-HTRs in gating plasticity induction in neocortical circuits remains unclear, with variable and seemingly contradictory effects reported for LTP induction in cortical sensory fields (e.g., V1, enhanced LTP: Inaba et al., 2009, Kojic et al., 1997,

As mentioned above variation of the A

2025-03-03

As mentioned above, variation of the A-ring was undertaken in order to improve microsomal stability and kinase selectivity relative to Polyphyllin VII (). 1-Imidazole-2-carboxamides with substitution at the 4-position (–) were mostly tolerated with 4-cyano-imidazole-2-carboxamide () having comparab

br Author contribution br Acknowledgement

2025-03-01

Author contribution Acknowledgement Introduction Since the initial finding of Gould et al. [1], showing the loss of dendritic spines in the hippocampus after ovariectomy and its rescue after treatment of the animals with estradiol, a tremendous number of studies have demonstrated a role of

br Results br Discussion br STAR Methods

2025-03-01

Results Discussion STAR★Methods Author Contributions Acknowledgments We thank Angela Walker for assistance with the manuscript; Junlin Liu, Xiangxiang Gu, Na Chen, Lu Xue, and the BV Core Facility of iHuman Institute for their support; scientists and colleagues at Amgen Inc., Zhulun W

In an effort to increase antioxidant properties of

2025-03-01

In an effort to increase antioxidant properties of peptides from WP, Le Maux et al. (2016) altered the hydrolysis conditions (pH, enzyme type, reaction time, and temperature). Hydrolysis of WP (81% protein) test samples with papain (EC 3.4.22.2) at a constant pH of 7.0 gave significantly higher ORAC

Introduction According to Uganda s Ministry of Health MOH a

2025-03-01

Introduction According to Uganda's Ministry of Health (MOH 2012a:91), intermittent preventive treatment (IPT) to avoid malaria during pregnancy is a free preventive service available to all pregnant women without clinical signs and symptoms of malaria, attending prenatal clinics. However, pregnant

br Model Fig demonstrates the block scheme of main interacti

2025-03-01

Model Fig. 1 demonstrates the block-scheme of main interactions between variables of the model under investigation. These interactions are described below in details and are expressed in mathematical form as well, where all variables are the functions of space and time coordinates, r and t, which