• br The Molecular Machinery of Autophagy and Regulation

  2024-09-06

  

  The Molecular Machinery of Autophagy and Regulation by Sphingolipids Sphingolipid-Mediated Autophagy in Cancer: Dr. Jekyll and Mr. Hyde Autophagy is an evolutionarily conserved stress response that typically promotes survival and antagonizes apoptosis. However, excessive autophagy was found to

• Mitochondrial dysfunction resulting from mtDNA abnormalities

  2024-09-05

  

  Mitochondrial dysfunction resulting from mtDNA abnormalities may trigger retrograde signaling pathways from the mitochondrion to the nucleus, which regulate the expression of genes involved in diverse cellular processes, including metabolism, stress responses, tumor progression, nutrient sensing, li

• Over expression of the inflammatory cytokines MMPs and COX

  2024-09-05

  

  Over expression of the inflammatory cytokines, MMPs and COX-2 act as an important inducer of chronic inflammation. COX-2 catalyzes the biosynthesis of prostaglandins (PGs), and induced expression was observed in protein kinase inhibitor stimulated with pro-inflammatory cytokines or bacterial lipopo

• Plant defensins Vriens et al and linear AMPs Domingues et

  2024-09-05

  

  Plant defensins (Vriens et al., 2014) and linear AMPs (Domingues et al., 2015, Liu et al., 2008) have been shown to present several modes of action. Among these different mechanisms, permeabilization of the fungal membrane has been described as a secondary effect of plant defensin action (Vriens et 

• In addition a substantial knowledge

  2024-09-05

  

  In addition, a substantial knowledge has been gained about the main properties of AT1R, such as ligand preference, signaling, regulation, and trafficking. However, it is less known how AT1R and other plasma membrane receptors affect each other’s function, and how these crosstalk mechanisms can be ut

• The RAS may have different functions depending

  2024-09-05

  

  The RAS may have different functions depending on whether we consider the circulatory component or the different local tissue systems (including brain) well described previously [29]. The cardiovascular control and hydroelectrolytic balance (among other functions), are largely the result of the infl

• Clinical observations of individuals with a decrease in LOX

  2024-09-05

  

  Clinical observations of individuals with a decrease in 12-LOX KY02111 are consistent with 12-LOX potentiating platelet activation and thrombus formation [40]. However, the relative contribution of 12-LOX to these complex disorders cannot be fully elucidated in the absence of a biochemical assessme

• br Conflict of interest statement br

  2024-09-05

  

  Conflict of interest statement Introduction Human saliva contains many detoxifying and antioxidant betamethasone celestone like glutathione S-transferase, catalase, peroxidase, aldehyde dehydrogenase (ALDH), etc. [1]. Human salivary ALDH (hsALDH) protects individuals from toxic aldehydes conta

• Recent studies demonstrated that AHR has an important role

  2024-09-05

  

  Recent studies demonstrated that AHR has an important role in the interplay between cancer metabolism and tumor-specific immunity. Tryptophan catabolism is increasingly recognized as a metabolic pathway that promotes tumorigenesis through its role in immune suppression [75]. The rate-limiting enzyme

• In a recent series of studies from our laboratory

  2024-09-05

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat mavacamten wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induced con

• br ABCA and cancer drug response Overall the expression

  2024-09-05

  

  ABCA2 and cancer drug response Overall, the expression of ABC transporters has been linked with multidrug resistance phenotypes through the efflux of drugs via ATP-dependent transport. For example, 13 distinct transporters (ABCA2, ABCB1, ABCB4, ABCB11, ABCC1–6 ABCC10, ABCC11 and ABCG2) have been

• Furthermore stress hormones can indirectly induce DNA damage

  2024-09-05

  

  Furthermore, stress hormones can indirectly induce DNA damage, for example by altering DNA repair and transcriptional regulation of the cell cycle. It has been found that stress hormones induce the up-regulation of checkpoint kinase 1 (Chk1) and checkpoint kinase 2 (Chk2) and proto-oncogene cell div

• In addition we aimed to examine the possible role of

  2024-09-05

  

  In addition, we aimed to examine the possible role of adiponectin in modulating changes in IR. It was observed that there was a simultaneous decline in expression of IR and AdipoR1 proteins in the ovary of PCOS-mice as compared to the control ovary. Further, a strong correlation was found between ch

• The synthetic route to M developed by

  2024-09-05

  

  The synthetic route to M100907 developed by Rice was utilized, however, the chiral resolution was carried out at an earlier stage to provide the possibility of introducing different substituents onto the piperidinyl group. The conditions for this resolution were different from previously reported.

• Introduction Myasthenia gravis MG is an autoimmune disorder

  2024-09-04

  

  Introduction Myasthenia gravis (MG) is an autoimmune disorder characterized by muscle weakness, which is mainly due to autoantibodies reducing the number or function of postsynaptic Kobe0065 receptors (AChRs) [1], [2]. Animal models have been developed to uncover the immunopathogenesis of MG. Expe

15944 records 85/1063 page Previous Next First page 上5页 8182838485 下5页 Last page