• Several studies on the collagen receptor DDR have revealed a

  2021-03-23

  

  Several studies on the collagen receptor DDR1 have revealed a defined collagen signaling pathway that causes cell scattering and cadherin switching. As mentioned earlier, DDR reboxetine on collagens are distinct from integrin binding sites; therefore, the same collagen protein can bind to DDR and i

• Another critical finding in this study

  2021-03-23

  

  Another critical finding in this study is that the level of αSyn oligomers in the SN of σ1R−/− mice was progressively increased with age, whereas the levels of αSyn monomers and αSyn messenger RNA (data not shown) were not altered compared to WT mice. A number of studies reported that soluble αSyn m

• The potential existence of ER stress was first

  2021-03-23

  

  The potential existence of ER stress was first examined in EVTs in placental bed biopsy specimens obtained from pregnancies complicated by early-onset preeclampsia. It was then tested whether ER stress can modulate MMP-2 activity before elucidating the role of proinflammatory cytokines in the induct

• The potential existence of ER stress was first

  2021-03-23

  

  The potential existence of ER stress was first examined in EVTs in placental bed biopsy specimens obtained from pregnancies complicated by early-onset preeclampsia. It was then tested whether ER stress can modulate MMP-2 activity before elucidating the role of proinflammatory cytokines in the induct

• MMAF Also our data from this study indicate that gestational

  2021-03-23

  

  Also, our data from this study indicate that gestational GC exposure altered hematological and hemorheological parameters, however reports exist that altered blood rheological markers are associated with atherosclerosis and CVD (Tzoulaki et al., 2007). Also, the platelet to lymphocyte ratio (PLR) ha

• Introduction Amphetamine AMPH methamphetamine MA and ethylen

  2021-03-23

  

  Introduction Amphetamine (AMPH), methamphetamine (MA), and 3,4-ethylenedioxymethamphetamine (MDMA) are widely abused psychoactive substances, with the basic chemical structure of phenylethylamine [1]. The abuse of these drugs is associated with psychostimulant, anorectic and hallucinogenic properti

• Arsenic could cause apoptosis in both benign and malignant c

  2021-03-23

  

  Arsenic could cause apoptosis in both benign and malignant cells (Akao et al., 2000, Gupta et al., 2003, Namgung and Xia, 2001). However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related proteins. In addition, the alte

• Introduction Cyclin dependent kinases CDKs

  2021-03-23

  

  Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as AZD6738 and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins/cyclin-like

• As mentioned above disruption of

  2021-03-22

  

  As mentioned above, disruption of Tgif1 in mice is associated with dyslipidemia, and here we investigate the effects of overexpression of TGIF1 on expression of the Npc1l1 gene and markers of intestinal cholesterol absorption. Materials and methods Results Discussion In this study, we soug

• For membrane protected SPE the choice of sorbent is

  2021-03-22

  

  For membrane protected μ-SPE, the choice of sorbent is crucial because it determines the extraction efficiency. Up to now, many porous materials, such as carbon based sorbents [1,[3], [4], [5], [6]], ethylsilane or octadecylsilane modified silica (C2 or C18) [7,8], polymeric materials [[9], [10], [1

• Other GPCRs notable for changes in expression on

  2021-03-22

  

  Other GPCRs notable for changes in expression on CLL cells include upregulation of the thromboxane A2 receptor TBXA2R mRNA [61] and up and downregulation of mRNA and protein from the neurotensin receptors NTSR2 and NTSR1, respectively [62]. The Eμ-TCL1 mouse model of CLL has been used to study mult

• Because EBI is expressed on the

  2021-03-22

  

  Because EBI2 is expressed on the major subsets of immune cells, and small molecule antagonists for EBI2 were recently described (Benned-Jensen et al., 2013, Gessier et al., 2014), EBI2 constitutes a tempting drug target reminiscent of the sphingosine-1-phosphate receptor superagonist fingolimod/Gile

• br GRAIL family Gene related to anergy in lymphocytes

  2021-03-22

  

  GRAIL family Gene related to anergy in lymphocytes protein (GRAIL, encoded by Rnf128 gene) is a transmembrane RING-type E3 ligase involved in T cell anergy and tolerance, and also regulation of FPH1 cytoskeletal organization [52]. This E3 was initially identified in CD4+ T helper cells and CD4+C

• The HEV vaccine developed based

  2021-03-22

  

  The HEV vaccine, developed based on p239 particles, is of good efficacy, immunogenicity and safety, and was licensed in China in 2012. p239 (aa 368–606) and E2 (aa 394–606) share a common region of ORF2, referred to as E2s (aa 459–606), which harbors the major antigenic determinants of the HEV vacci

• A number of studies have been carried out to understand

  2021-03-22

  

  A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key bruton's tyrosine kinase of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica napus, Arab

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